Your immune system is your body's defense against illness, and enhancing it naturally can improve your overall well-being. Among the most promising natural solutions are functional mushrooms, nutrient-rich fungi used for centuries in traditional medicine.
Recent research shows that these fungi do more than just help fight colds; they may influence genetic expression through epigenetic pathways. Combined with protein peptides, they support resilience, cognition, and longevity.
Learn how these superfood mushrooms and peptides can work together to enhance immune strength, modulate gene activity, and optimize your health.
Related product: Be•Well Organic Mushroom Blend
Mushrooms to boost your immune system
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Reishi
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Chaga
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Cordyceps
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Lion’s Mane
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Oyster
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Shiitake
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Maitake
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Turkey Tail
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King Trumpet
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Agaricus Blazei
1. Reishi
This mushroom contains bio-components whose effects may reverse many factors of immune senescence, which is the gradual deterioration of the immune system due to aging. Reishi enhances the innate immune cells.
It contains constituents such as polysaccharides, which stimulate macrophages (these guys recognize and gobble up foreign invaders like bacteria, viruses, and harmful fungi). They also help reduce the allergic reaction while strengthening digestive organs, protect the gut lining, lower inflammation, inhibit histamine release, and improve oxygen utilization and liver function.
Other benefits:
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Prevents abnormal blood vessel formation
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Reduces risk of cognitive disorders (boosts concentration & focus)
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Lowers cholesterol
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Reduces the risk of chronic diseases and premature aging
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Effective in treating arthritis or gout
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Help prevent and treat cancer
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Detoxifies the body and boosts energy levels
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Relieves chronic respiratory conditions
All of the above items are usually associated with a compromised immune system.
(Note: Mushrooms can help boost your immune system but so can Sunwarrior's Immune Shield. Treat and protect your body! Learn more here.)
2. Chaga
Much like it’s relative Reishi, Chaga has a plethora of benefits apart from immunity. Due to a number of nutrients, it contains numerous B vitamins, flavonoids, phenols, and enzymes. It is also one of the world’s densest sources of pantothenic acid – a vitamin needed not only by the immune system but by the adrenal glands that help us deal with stress, and shows some love to the digestive organs.
Chaga is high in wild-sourced minerals, particularly copper, calcium, potassium, manganese, zinc, and iron, all of which are necessary for maintaining optimal health. The real star of the show, however, is superoxide dismutase (SOD). Our body naturally produces this antioxidant enzyme which is a free radical scavenger acting as a “bodyguard” protecting against DNA damage and mutation, reducing the work needed from the immune system and therefore indirectly enhancing it.
Although Reishi showed an increased SOD by 1,400 units per gram, Chaga contained a staggering 35,000 units per gram. Take that, free radicals! Additionally, Chaga also helps to directly reduce inflammation in the body.
Other benefits:
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Contains Beta D-Glucans (like reishi) – also regulates and enhances the immune system
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Phytosterols – lowers cholesterol
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Melanin – high antioxidant potential
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Polyphenols – reduces free radicals and cardiovascular diseases
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Polysaccharides – anti-viral
3. Cordyceps
This mushroom is great for maintaining optimal immune function, increasing energy throughout the day, and as a pre-workout booster. It has been suggested that Cordyceps stimulates the immune system by increasing the number of white blood cells (WBCs)–the body’s first line of defense against various infections.
Apart from an increase of WBCs, it elevates T-helper cells, those natural killer cells, and macrophages, which we previously said manifest in response to increased cellular immunity fighting against infection, especially viral and fungal.
Cordyceps also have similar polysaccharides that fight against free radicals (remember SOD?) This mushroom also contains the ability to up-regulate the production of this amazing antioxidant along with another one called glutathione, which is also extremely powerful and beneficial against free radical damage as it helps detoxify the body.
Related product: Be•Well Organic Matcha Mushroom Powder
Other benefits:
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Inhibits growth of cancer cells
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Anti-inflammatory by suppressing the production of COX-2, NFkB, and TNFa (molecules present in cancer)
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Inhibits metastasis and spreading of some cancers
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Helps those who already have cancer and take chemo to have less fatigue and pain
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Anti-viral and anti-bacterial properties which help protect infections in cancer patients and those who recently had surgery
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Effective in relaxing and opening breathing passages and used in the treatment of upper respiratory tracts, such as pneumonia, chronic bronchitis, pulmonary emphysema, and tuberculosis
4. Lion’s Mane
Hericium Erinaceus is commonly known as Lion’s Mane due to its fur-like white appearance. Lion’s Mane is often used for a brain boost to help cognitive function and provide better mental clarity. The mushroom is packed with antioxidants that strengthen the immune system, similar to other medicinal mushrooms.
Lion’s Mane contains a unique property. It stimulates the production of bioprotein nerve growth factor (NFG) and myelin. Myelin is the insulation surrounding nerve fibers. Both myelin and NFG are vital for brain health. Research suggests that an imbalance in them can contribute to brain disorders like Alzheimer’s disease and multiple sclerosis.
Other benefits:
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Improve memory
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Increase concentration
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Ease anxiety and irritability
Related product: Be•Well Organic Lion's Mane Mushroom Powder
5. Oyster Mushrooms
Oyster mushrooms are not only delicious but have a lot of health benefits. The oyster mushroom family contains several species. The traditional oyster mushroom known as Pleurotus ostreatus is the one you’re most likely to find in the grocery store. Other types of oyster mushrooms include king oyster, pink oyster, pearl oyster, and blue oyster.
Initial in-vitro research shows that the polysaccharides in Pleurotus ostreatus mushrooms, a type of oyster mushroom, inhibits natural killer cells in lung and breast cancer cells.
Oyster mushrooms are great for overall health and the immune system as they are packed with antioxidants, vitamin D, and iron. Like other medicinal mushrooms, oyster mushrooms contain beta-glucans which is one of the best foods on the planet for protecting your immune system against both long and short-term illnesses.
Other benefits:
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Build strong bones
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Lower blood pressure
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Anti-inflammatory properties
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Protect against cardiovascular disease
6. Shiitake
Traditionally, shiitake mushrooms have been used to treat ailments like the common cold. A four-week clinical trial found that shiitake mushroom intake was associated with positive changes in various immune compounds. It’s thought that these changes may support improvements in gut health and anti-inflammatory response. As with other medicinal mushrooms, shiitake mushrooms contain anti-cancer properties.
Other benefits:
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May support heart health
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Antibacterial and antiviral effects
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Strengthen bones
7. Maitake
Maitake is a medicinal and culinary mushroom. Research suggests it has anti-cancer properties and immune-boosting effects. One of the main components of maitake mushrooms, proteoglycan, is associated with immune-stimulating effects.
Maitake mushrooms are a type of adaptogen. Adaptogens help the body to fight any physical or mental difficulties. They also help to rebalance systems in the body that are out of sync. Generally, this type of mushroom has an overall positive effect on the immune system as it is rich in antioxidants, beta-glucans, vitamins B and C, and fiber.
Other benefits:
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May lower cholesterol and blood pressure
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May support weight loss
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Combat tumors
8. Turkey Tail
The turkey tail mushroom gets its name from its brown rings on the surface, similar to the tail feathers of a turkey. Traditionally, turkey tail mushrooms have been used to treat fungal infections and cancer. It contains powerful antioxidants that help support the immune system and fight off colds and infection.
Keeping a healthy balance of bacteria in the gut is associated with a strong immune system. Research suggests that turkey tail mushrooms may enhance gut health as it contains prebiotics that feed and nourish the good bacteria in your gut.
Turkey tail mushrooms contain Polysaccharide Peptide (PSP), a type of immune-boosting compound. In an eight-week study, participants consumed 3,600 mg of PSP extracted from turkey tail mushrooms every day. Researchers observed beneficial changes in the gut that suppressed harmful bacteria in the gut like E. coli and Shigella bacteria. These types of bacteria can cause health problems like diarrhea, fever, and stomach cramps.
Other benefits:
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Reduce inflammation
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May improve athletic performance
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Antibacterial properties
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May improve insulin resistance
