Why are natural vitamins often preferred over synthetic ones? Do synthetic vitamins provide the same health benefits? How can you ensure you’re getting the best nutrients for your body?
Our bodies rely on essential vitamins to function properly. While vitamins can be obtained from both natural and synthetic sources, the debate between natural vs. synthetic vitamins continues to be a hot topic. Understanding their differences can help you make more informed decisions about your supplements and overall health.

What Is Pyridoxine Hydrochloride?
Pyridoxine hydrochloride is a form of vitamin B6 that is commonly used in supplements and fortified foods. Vitamin B6 is essential for metabolism, brain function, and immune health. However, there is an ongoing debate about whether pyridoxine hydrochloride is a natural or synthetic form of vitamin B6.
Is Pyridoxine Hydrochloride Synthetic or Natural?
Pyridoxine hydrochloride is a synthetic form of vitamin B6. It is chemically produced in laboratories rather than extracted from food sources. This version is often used in dietary supplements due to its stability and cost-effectiveness. While it is bioavailable, its absorption and utilization may differ from the natural form found in whole foods.
Synthetic vs. Natural Vitamin B6 (Pyridoxine HCl)
The natural form of vitamin B6, known as pyridoxal-5-phosphate (P5P), is found in foods like bananas, poultry, and potatoes. P5P is the active form of vitamin B6 that the body can readily use. On the other hand, pyridoxine hydrochloride must be converted into P5P before the body can utilize it, which can make it less effective for some individuals.
Is Pyridoxine Hydrochloride Bad for You?
While pyridoxine hydrochloride is generally considered safe, high doses can lead to nerve damage and other side effects. Some people may also have difficulty converting synthetic B6 into its active form, leading to potential deficiencies despite supplementation. Opting for natural sources of vitamin B6 or plant-based supplements and vitamins can be a better choice.
Thiamine Mononitrate vs. Natural Thiamine: What You Need to Know
Thiamine (vitamin B1) is essential for energy production and nerve function. Thiamine mononitrate is a synthetic form commonly found in processed foods and supplements. Natural sources of thiamine include whole grains, nuts, and legumes. While both forms can prevent deficiencies, natural thiamine is more easily absorbed and utilized by the body.
Is Riboflavin Synthetic? Understanding the Truth About Vitamin B2
Riboflavin (vitamin B2) can be obtained from both synthetic and natural sources. The synthetic form, often listed as riboflavin-5-phosphate, is created through fermentation or chemical synthesis. Natural sources include dairy products, eggs, and leafy greens. While synthetic riboflavin is bioavailable, natural riboflavin from food sources is often more effective.

How Synthetic B Vitamins Are Made (Especially Pyridoxine Hydrochloride)
Synthetic B vitamins, including pyridoxine hydrochloride, are often produced through chemical synthesis using petroleum derivatives, genetically modified bacteria, or fermentation processes. This allows for mass production at a lower cost, but it can also result in vitamins that are not as bioavailable as their natural counterparts.
Common Names for Synthetic B Vitamins
Understanding the different names for synthetic B vitamins can help you make better choices when purchasing supplements. Some common synthetic B vitamin names include:
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Pyridoxine hydrochloride (synthetic B6)
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Thiamine mononitrate (synthetic B1)
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Riboflavin-5-phosphate (synthetic B2)
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Folic acid (synthetic B9)
Are Synthetic Vitamins as Effective as Natural Ones?
While synthetic vitamins can help prevent deficiencies, they often lack the full spectrum of nutrients found in whole foods. Many synthetic vitamins are isolated compounds that do not include the natural cofactors needed for optimal absorption. plant-based detox provides a more balanced approach by delivering vitamins in their natural state, ensuring better bioavailability.
How Can I Get Enough Vitamin B6 Naturally?
If you’re looking to boost your vitamin B6 intake naturally, focus on whole foods such as:
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Bananas
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Chickpeas
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Poultry (chicken, turkey)
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Potatoes
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Sunflower seeds
Additionally, vegan multi-v, vegan collagen, and plant-based protein powder can help support your nutrient intake if you follow a plant-based diet.
Natural vs. Synthetic Vitamins
Vitamin A
- Natural Vitamin A – Vitamin A shows up in food as beta-carotene. The body must convert it into vitamin A to be useful. This sounds less effective, but vitamin A can be toxic in large doses. Beta-carotene allows the body to convert what it needs and discard what it does not as a natural safeguard against damage.
- Synthetic Vitamin A – Synthetic vitamin A is retinyl palmitate or retinyl acetate. This synthetic is made from combining fish or palm oil with beta-ionone. Palm oil is leading to deforestation of rainforest and endangerment of orangutans. Beta-ionone is created using citrus, acetone, and calcium oxide.
Vitamin B1
- Natural Vitamin B1 – Thiamin, or vitamin B1, is a water soluble vitamin created by plants and bound to phosphate. Digestion releases the thiamin using specialized enzymes that target phosphate.
- Synthetic Vitamin B1 – Thiamine mononitrate or thiamine hydrochloride is made from coal tar, ammonia, acetone, and hydrochloric acid. It is much less absorbable since it isn’t bound to phosphate. It is crystalline in structure, unlike plant-based vitamins. Many synthetic vitamins are crystalline. Crystals in our blood stream cause damage and mineral accumulation where it isn’t needed, like joints.
Vitamin B2
- Natural Vitamin B2 – Riboflavin is easily absorbed, stays in the blood stream for long periods of time, and is readily used by the body in many important enzymes.
- Synthetic Vitamin B2 – Synthetic riboflavin is made with acetic acid and nitrogen or using genetically modified bacteria and fermentation. It has been shown to be less absorbable and then quickly removed from the blood stream and expelled in urine like a toxin would be.

Vitamin B3
- Natural Vitamin B3 – Niacinamide or nicotinamide is what we find in food and commonly call niacin. Niacin can have side effects, but these are minimal when coming from plant foods.
- Synthetic Vitamin B3 – Nicotinic acid is created using coal tar, ammonia, acids, 3-cyanopyridine, and formaldehyde. It is less absorbable and has more risks of side effects.
Vitamin B5
- Natural Vitamin B5 – Pantothenate is the natural version of this essential B vitamin.
- Synthetic Vitamin B5 – Pantothenic acid involves isobutyraldehyde and formaldehyde to form a calcium or sodium salt. The alcohol derivative, panthenol, is sometimes used as it is more stable and lasts longer on store shelves.
Vitamin B6
- Natural Vitamin B6 – Like B1, pyridoxine is bound with phosphate in plants to make pyridoxal-phosphate. This is the biologically active form. Any other form of B6 must be converted into this phosphate combination before our body can use it.
- Synthetic Vitamin B6 – Pyridoxine hydrochloride comes from petroleum ester, hydrochloric acid, and formaldehyde. It isn’t readily absorbed or converted and has been shown to actually inhibit the action of natural B6 in the body. It also has side effects not normally found with natural food sources of this vitamin.
Vitamin B7
- Natural Vitamin B7 – Biotin is involved in cell growth, fat production, and metabolism.
- Synthetic Vitamin B7 – Synthetic B7 is produced using fumaric acid.
Vitamin B9
- Natural Vitamin B9 – This B vitamin exists in food as folate and is very important in the creation and repair of DNA, thus the vital importance of this vitamin before and during pregnancy.
- Synthetic Vitamin B9 – Folic acid doesn’t exist in natural foods, is crystalline, and is not easily absorbed despite the large amounts that are added to vitamins and supplements. It comes from petroleum derivatives, acids, and acetylene.
Vitamin B12
- Natural Vitamin B12 – Cobalamin B12 is only created by micro-organisms like the bacteria that grow in soil and our intestines, as well as some micro-algae and perhaps some seaweed species.
- Synthetic Vitamin B12 – Cobalt and cyanide are fermented to make cyanocobalamin. That’s correct. Cyanide. It is in miniscule amounts, but it is still cyanide.
Choline
- Natural Choline – Choline is often grouped with B vitamins. It is combined with phosphate in nature and is important in cell membranes and keeping fat in check.
- Synthetic Choline – Choline chloride or choline bitartrate is made using ethylene, ammonia, and hydrochloric acid or tartaric acid. It is not bound to phosphate.
Vitamin C
- Natural Vitamin C – This vitamin is readily available in citrus, red bell peppers, berries, and many more fruits and vegetables. In nature it is combined with flavonoids and phytonutrients that help in its absorption and use.
- Synthetic Vitamin C – Ascorbic acid is an isolated vitamin from genetically modified corn sugar that is hydrogenated and processed with acetone. It does not include the flavonoids and phytonutrients that make it work.
Vitamin D
- Natural Vitamin D – Technically this one isn’t always thought of as a vitamin since we make it ourselves. Mushrooms, yeast, and lichen produce vitamin D when exposed to sunlight. Humans do too. A daily dose of about 20 minutes of sunlight provides all we need. Vitamin D3 is the most effective kind, the same that comes from our own skin and lichen. Mushrooms and yeast often yield D2.
- Synthetic Vitamin D – To mimic the natural production we find in our skin, scientists irradiate animal fat to stimulate vitamin D3 synthesis. They usually use lanolin, the waxy secretions from sheep skin that keeps wool dry.
Vitamin E
- Natural Vitamin E – Vitamin E actually refers to 8 different fat soluble compounds and it acts as an antioxidant that protects fats from oxidation. The most biologically active form is found in grains, seeds, and the oils from grains and seeds.
- Synthetic Vitamin E – The synthetic dl-alpha tocopherol is created using refined oils, trimethylhydroquinone, and isophytol. It is not as easily absorbed, doesn’t stay as long in tissues, and is quickly dispelled like a toxin or unknown chemical.
Vitamin K
- Natural Vitamin K – This vitamin is important to proper blood clotting and some metabolic pathways. It is found in dark leafy greens.
- Synthetic Vitamin K – Synthetic vitamin K, menadione, comes from coal tar derivatives and genetically modified and hydrogenated soybean oil, and uses hydrochloric acid and nickel. It is considered highly toxic and damages the immune system. Vitamins should really come from food sources as much as possible. If you want a multivitamin, reach for ones that use whole food sources like holy basil, guava, and other herbs, fruits, and vegetables.
Conclusion
The debate between natural vs. synthetic vitamins is ongoing, but one thing is clear: natural sources tend to be more bioavailable and beneficial for long-term health. While synthetic vitamins can help bridge nutritional gaps, whole foods and plant-based supplements and vitamins are often the superior choice.
By opting for Vitamin Mineral Rush in Aloe Vera Superjuice, Liquid Light, and other natural supplements, you can ensure your body receives the best possible nutrients in the most effective form. Choosing wisely can make all the difference in your overall well-being.
FAQs
What is pyridoxine hydrochloride?
Pyridoxine hydrochloride is a synthetic form of vitamin B6 commonly used in supplements.
Is pyridoxine hydrochloride synthetic or natural?
It is a synthetic form of vitamin B6, created through chemical processes.
What is pyridoxine hydrochloride made from?
It is typically synthesized using petroleum derivatives or fermentation techniques.
Is pyridoxine hydrochloride bad for you?
In moderate doses, it is safe, but excessive intake can lead to nerve damage.
What is thiamine mononitrate, and is it synthetic?
Thiamine mononitrate is a synthetic form of vitamin B1, commonly added to processed foods and supplements.
What is the difference between natural and synthetic vitamin B6?
Natural B6 (P5P) is readily usable by the body, while synthetic B6 (pyridoxine hydrochloride) requires conversion.
Is riboflavin synthetic?
It can be either natural or synthetic. Synthetic riboflavin is produced through chemical or fermentation processes.
What are synthetic B vitamins used for?
They are used to prevent deficiencies and are often found in fortified foods and supplements.
Are synthetic vitamins as effective as natural ones?
Synthetic vitamins can help prevent deficiencies, but natural sources are often more bioavailable and beneficial.
How can I get enough vitamin B6 naturally?
Consume foods like bananas, poultry, chickpeas, and plant-based supplements and vitamins for optimal intake. For more natural health solutions, visit Sunwarrior.